Effects of Nicotine on the Neurophysiological and Behavioral Effects of Ketamine in Humans
Background: N-methyl-D-aspartate (NMDA) receptor hypofunction has been implicated in the pathophysiology of schizophrenia and its associated neurocognitive impairments.The high rate of cigarette smoking in schizophrenia raises questions about how nicotine modulates putative NMDA receptor hypofunction in the illness.Accordingly, we examined the modu